Breast Sarcomas, Phyllodes Tumors, and Desmoid Tumors: Epidemiology, Diagnosis, Staging, and Histology-Specific Management Considerations

Breast sarcomas arise from connective tissues of the breast and account for fewer than 1% all malignancies. They can be subclassified as primary sarcomas, which de novo are histologically diverse, secondary a result radiation or lymphedema most commonly angiosarcomas. Two other tissue neoplasms that occur within include phyllodes tumors desmoid tumors, exhibit spectrum behaviors. Malignant biologically similar to whereas technically benign but often locally aggressive. Patients with present rapidly growing mass or, in cases radiation-associated angiosarcoma, violaceous cutaneous lesions. Core needle biopsy is generally required confirm diagnosis sarcomas. Staging workup includes MRI chest imaging, although these not case tumors. In general, localized should resected, extent resection tailored histologic subtype. Radiation chemotherapy used neoadjuvant adjuvant setting, data limited, so treatment decisions made on an individualized basis. Systemic therapy options metastatic disease refractory desmoids mimic those same histologies when sites. Given rarity heterogeneity sarcoma, well limited literature describing entities, expert multidisciplinary evaluation crucial optimal decision making.